Research Articles
Chemical-Genetic Interactions and Fitness Scoring: From Foundational Concepts to Advanced Applications in Drug Discovery
This article provides a comprehensive overview of chemical-genetic (C-G) interaction profiling and fitness scoring, a powerful systems biology approach for elucidating small molecule mechanism of action (MOA).
In Silico Chemogenomics: The AI-Powered Future of Drug Discovery
This article provides a comprehensive overview of in silico chemogenomics, a discipline that systematically identifies small molecules for protein targets using computational tools.
High-Throughput Chemogenomic Screening: Methods, Applications, and AI-Driven Advances in Drug Discovery
This article provides a comprehensive overview of high-throughput chemogenomic screening methods, a powerful approach that integrates genomics and chemical biology to accelerate therapeutic discovery.
A Scalable CRISPRi Chemical Genetics Platform: Protocol for High-Throughput Target Deconvolution and Mechanism of Action Studies
This article provides a comprehensive guide to implementing a scalable CRISPR interference (CRISPRi) chemical genetics platform for drug discovery.
Target Families in Chemogenomics: A 2025 Guide to Multi-Target Drug Discovery
This article provides a comprehensive overview of chemogenomics and its application to target families for researchers and drug development professionals.
The Convergence Code: How Integrating Chemistry, Biology, and Informatics is Revolutionizing Drug Discovery
This article explores the transformative paradigm of integrative chemistry, biology, and informatics in modern therapeutic development.
Chemical Genetics: Basic Concepts, Methodologies, and Applications in Modern Drug Discovery
This article provides a comprehensive overview of chemical genetics, a research approach that uses small molecules as probes to study gene and protein functions in biological systems.
Chemogenomic Compound Libraries: Principles, Applications, and Future Directions in Drug Discovery
This article provides a comprehensive overview of chemogenomic compound libraries, which are collections of well-annotated small molecules designed to systematically probe the functions of a wide range of protein targets.
Chemical Biology Approaches for Target Validation: Current Strategies and Future Directions in Drug Discovery
This article provides a comprehensive overview of modern chemical biology approaches for target validation in drug discovery.
SAR Matrix Analysis: From Ligand-Target Predictions to Accelerated Drug Discovery
This article provides a comprehensive overview of Structure-Activity Relationship (SAR) matrix analysis for ligand-target prediction, a critical computational approach in modern drug discovery.