Research Articles
Benchmarking Drug-Target Interaction Prediction: A Comprehensive Guide to Methods, Challenges, and Future Directions
This article provides a comprehensive analysis of the current landscape of drug-target interaction (DTI) prediction benchmarking.
Overexpression vs Knockdown Screens: A Comprehensive Guide for Functional Genomics and Drug Discovery
This article provides a systematic comparison of overexpression (gain-of-function) and knockdown (loss-of-function) genetic screens, two pivotal methodologies in functional genomics.
Chemical Genetics Unveils Cross-Resistance Patterns: A Systematic Framework for Smarter Drug Development
This article explores how chemical genetics, a high-throughput functional genomics approach, is revolutionizing our understanding of cross-resistance and its counter-phenomenon, collateral sensitivity.
Chemogenomic Signature Similarity Analysis: A Powerful Framework for Accelerating Drug Discovery and Target Identification
This article provides a comprehensive overview of chemogenomic signature similarity analysis, a powerful methodology that connects chemical and genomic information to drive drug discovery.
Comparative Chemical Genomics Across Species: Unlocking Evolutionary Secrets for Drug Discovery
Comparative chemical genomics is a powerful paradigm that systematically investigates the interactions of small molecules with biological systems across diverse species.
Validating Chemogenomic Hit Genes: Strategies for Target Confirmation in Drug Discovery
This comprehensive review addresses the critical challenge of validating chemogenomic hit genes in modern drug discovery.
Batch Effect Correction in Chemogenomics: A Comprehensive Guide for Robust Data Integration and Drug Discovery
Systematic technical variations, or batch effects, are a pervasive challenge in chemogenomic data, potentially confounding the identification of true biological signals and leading to misleading conclusions in drug discovery.
Solving CRISPRi Knockdown Efficiency: A Researcher's Guide to Troubleshooting and Optimization
This article provides a comprehensive, step-by-step framework for researchers and drug development professionals to diagnose and resolve common issues with CRISPR interference (CRISPRi) knockdown efficiency.
Automating Discovery: Advanced Strategies for High-Throughput Chemical Genetic Screens
This article provides a comprehensive overview of modern automation strategies revolutionizing chemical genetic screening.
Optimizing NGS Workflows for Chemogenomics: A Strategic Guide to Enhance Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on optimizing Next-Generation Sequencing (NGS) workflows specifically for chemogenomics applications.