Research Articles
Overcoming Class Imbalance in Drug-Target Interaction Prediction: Strategies, Benchmarks, and Future Directions
Accurate prediction of Drug-Target Interactions (DTIs) is crucial for accelerating drug discovery, yet it is severely challenged by class imbalance, where known interacting pairs are vastly outnumbered by non-interacting ones.
Improving Chemogenomic Signature Analysis: Strategies for Robustness, AI Integration, and Clinical Translation
This article provides a comprehensive guide for researchers and drug development professionals on advancing chemogenomic signature analysis.
Overcoming the Cold-Start Challenge in Drug-Target Interaction Prediction: Modern Computational Strategies
Accurate prediction of Drug-Target Interactions (DTIs) is fundamental to accelerating drug discovery and repurposing.
Strategic Blueprint for Optimizing Chemogenomic Library Diversity in Modern Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on optimizing chemogenomic library diversity, a critical factor for successful phenotypic screening and target deconvolution.
Phenotypic Screening Meets Chemogenomics: A Modern Strategy for Target Deconvolution and Drug Discovery
This article explores the powerful synergy between phenotypic screening and chemogenomics, a strategy that is reshaping modern drug discovery.
Structure-Based Chemogenomics: Integrating AI and Computational Biology for Accelerated Drug Discovery
This article provides a comprehensive overview of structure-based chemogenomic methods, an interdisciplinary strategy that systematically links chemical compounds to biological targets to streamline drug discovery.
Network-Based Inference for Drug-Target Prediction: A Comprehensive Guide from Foundations to Clinical Applications
This article provides a comprehensive overview of network-based inference (NBI) methods for predicting drug-target interactions (DTIs), a crucial task in modern drug discovery and repurposing.
Building a Robust Comparative Chemical Genomics Pipeline for Antimicrobial Resistance Profiling
This article provides a comprehensive guide for developing and implementing a comparative chemical genomics pipeline to study antimicrobial resistance mechanisms.
Strategic Design and Application of Chemogenomic Libraries in Precision Oncology
This article provides a comprehensive guide for researchers and drug development professionals on the strategic design and application of chemogenomic libraries.
Haploinsufficiency Profiling (HIP): A Comprehensive Guide to Drug Target Identification and Mechanism of Action
Haploinsufficiency Profiling (HIP) is a powerful chemogenomic approach that systematically identifies drug targets by exploiting the phenomenon of drug-induced haploinsufficiency in heterozygous diploid strains.