Research Articles
Gene Fitness Under Toxin Stress: Profiling Methods, Applications in Drug Discovery, and Future Directions
This article provides a comprehensive overview of modern strategies for profiling the fitness contributions of genes under toxin-induced stress, a critical area in toxicogenomics and drug development.
Comparative Genomic Fingerprinting (CGF): Protocols, Applications, and Best Practices for Pathogen Surveillance and Drug Discovery
This article provides a comprehensive guide to Comparative Genomic Fingerprinting (CGF), a high-resolution molecular subtyping method that analyzes the presence or absence of accessory genes to generate unique genetic fingerprints.
Shared Toxicity Mechanisms in Protein Hydrolysates: Identification, Analysis, and Clinical Implications for Safer Therapeutic Development
This article provides a comprehensive analysis for researchers and drug development professionals on identifying and understanding shared toxicity mechanisms across different protein hydrolysates.
Comparative Genomics in P-type ATPase Inhibitor Discovery: From Target Identification to Therapeutic Applications
This article explores the transformative role of comparative genomics in discovering and developing P-type ATPase inhibitors, a class of enzymes crucial for cellular ion homeostasis and promising therapeutic targets.
Cross-Species Chemical Genomics: A One Health Strategy for Combating Infectious Diseases and Antimicrobial Resistance
This article explores the transformative potential of cross-species chemical genomics in infectious disease research and drug development.
Chemical Genetic Interactions: Leveraging Yeast and Parasite Models for Antiparasitic Drug Discovery
This article explores the transformative role of chemical genetic interactions in accelerating drug discovery, with a focus on yeast and parasite models.
Using Comparative Genomics to Identify Novel Antimicrobial Peptides: A Strategy to Combat Drug-Resistant Superbugs
The escalating global health crisis of antimicrobial resistance necessitates the discovery of novel therapeutic agents.
Evolutionary Conservation of Drug Targets: A Cross-Eukaryotic Guide for Target Discovery and Validation
This article provides a comprehensive analysis of the evolutionary conservation of drug targets across diverse eukaryotic species, a critical consideration for modern drug discovery.
Comparative Chemical Genomics: A Systematic Framework for Mechanism of Action Discovery in Drug Development
This article provides a comprehensive overview of comparative chemical genomics, an integrative approach that combines large-scale genetic perturbations with chemical screening to elucidate drug mechanisms of action (MoA).
Chemical Genomic Profiling for Target Deconvolution: Cross-Species Strategies and Advanced Applications in Drug Discovery
This article provides a comprehensive overview of chemical genomic profiling as a powerful, unbiased approach for target deconvolution in phenotypic drug discovery.