Research Articles
Phenotypic Screening Meets Chemogenomics: A Modern Strategy for Target Deconvolution and Drug Discovery
This article explores the powerful synergy between phenotypic screening and chemogenomics, a strategy that is reshaping modern drug discovery.
Structure-Based Chemogenomics: Integrating AI and Computational Biology for Accelerated Drug Discovery
This article provides a comprehensive overview of structure-based chemogenomic methods, an interdisciplinary strategy that systematically links chemical compounds to biological targets to streamline drug discovery.
Network-Based Inference for Drug-Target Prediction: A Comprehensive Guide from Foundations to Clinical Applications
This article provides a comprehensive overview of network-based inference (NBI) methods for predicting drug-target interactions (DTIs), a crucial task in modern drug discovery and repurposing.
Building a Robust Comparative Chemical Genomics Pipeline for Antimicrobial Resistance Profiling
This article provides a comprehensive guide for developing and implementing a comparative chemical genomics pipeline to study antimicrobial resistance mechanisms.
Strategic Design and Application of Chemogenomic Libraries in Precision Oncology
This article provides a comprehensive guide for researchers and drug development professionals on the strategic design and application of chemogenomic libraries.
Haploinsufficiency Profiling (HIP): A Comprehensive Guide to Drug Target Identification and Mechanism of Action
Haploinsufficiency Profiling (HIP) is a powerful chemogenomic approach that systematically identifies drug targets by exploiting the phenomenon of drug-induced haploinsufficiency in heterozygous diploid strains.
Chemical-Genetic Interactions and Fitness Scoring: From Foundational Concepts to Advanced Applications in Drug Discovery
This article provides a comprehensive overview of chemical-genetic (C-G) interaction profiling and fitness scoring, a powerful systems biology approach for elucidating small molecule mechanism of action (MOA).
In Silico Chemogenomics: The AI-Powered Future of Drug Discovery
This article provides a comprehensive overview of in silico chemogenomics, a discipline that systematically identifies small molecules for protein targets using computational tools.
High-Throughput Chemogenomic Screening: Methods, Applications, and AI-Driven Advances in Drug Discovery
This article provides a comprehensive overview of high-throughput chemogenomic screening methods, a powerful approach that integrates genomics and chemical biology to accelerate therapeutic discovery.
A Scalable CRISPRi Chemical Genetics Platform: Protocol for High-Throughput Target Deconvolution and Mechanism of Action Studies
This article provides a comprehensive guide to implementing a scalable CRISPR interference (CRISPRi) chemical genetics platform for drug discovery.