Research Articles
Beyond the Hype: A Data-Driven Framework to Fix Low Hit Rates in Virtual Screening
This article provides a comprehensive guide for computational chemists and drug discovery scientists struggling with low hit rates in virtual screening (VS).
Addressing Data Bias in Structure-Based Chemogenomic Models: Strategies for Robust AI-Driven Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on identifying, mitigating, and validating solutions to data bias in structure-based chemogenomic models.
Beyond the Majority: Advanced Strategies for Handling Class Imbalance in Chemogenomic Drug Discovery Models
This article provides a comprehensive guide for researchers and drug development professionals tackling the pervasive challenge of class imbalance in chemogenomic classification.
Ligand Efficiency in Drug Discovery: A Critical Comparison of HTS and Fragment-Based Screening Strategies
This article provides a comprehensive analysis and comparison of ligand efficiency metrics as applied to High-Throughput Screening (HTS) and Fragment-Based Screening (FBS).
HIPHOP Profiling in Yeast: A Comprehensive Guide to Chemogenomic Assays for Drug Discovery
This article provides a detailed guide to HIPHOP (Homozygous Profiling and Heterozygous Profiling) chemogenomic assays in Saccharomyces cerevisiae.
Unlocking Drug Discovery: A Comprehensive Guide to HIPHOP Chemogenomic Screening Methodology
This article provides a detailed exploration of HIPHOP (Heterodimer Induction by PrOmiscuous ligands) chemogenomic screening, a powerful phenotypic methodology for identifying protein-protein interaction (PPI) modulators.
Mechanism of Action Decoded: HIP vs. Transcriptomics in Modern Drug Discovery
This article provides a comprehensive comparison of two leading methodologies for elucidating drug Mechanism of Action (MoA): High-throughput Imaging-based Profiling (HIP) and transcriptomics.
HIP HOP Assay: The Definitive 2024 Comparison Guide for Drug Discovery & Protein-Protein Interaction Research
This comprehensive guide demystifies the HIP (Heterodimerization-Induced Protein) and HOP (Homodimerization-Induced Protein) assay systems, two pivotal technologies for studying protein-protein interactions (PPIs) in drug discovery.
HIP vs CRISPR Screens: A Comparative Guide to Functional Genomics for Drug Discovery
This article provides a comprehensive, side-by-side analysis of two powerful functional genomics screening technologies: Highly Parallel Phenotyping (HIP) and CRISPR-based screens.
Mastering HIP-Target Identification: A Comprehensive Guide to Principles, Methods, and Best Practices for Drug Discovery
This article provides a systematic guide to Historically Illuminating Pair (HIP) target identification, a crucial bioinformatics strategy in modern drug discovery.