Research Articles
Optimizing High-Content Phenotypic Screening Protocols: From Foundational Principles to AI-Enhanced Workflows
This article provides a comprehensive guide for researchers and drug development professionals on optimizing high-content phenotypic screening (HCS) protocols.
High-Content Imaging in Phenotypic Screening: A Chemogenomic Approach to Modern Drug Discovery
This article explores the integration of high-content imaging (HCI) and chemogenomic libraries in phenotypic screening, a powerful strategy revitalizing drug discovery.
Chemogenomics Libraries: Unlocking the Druggable Genome for Targeted Drug Discovery
This article provides a comprehensive overview of chemogenomics libraries, which are rationally assembled collections of small molecules designed to systematically probe the druggable genome.
Phenotypic Screening for Novel Mechanism of Action (MoA) Discovery: Strategies, AI Integration, and Future Directions
This article provides a comprehensive overview of phenotypic screening as a powerful, unbiased strategy for discovering novel therapeutic mechanisms of action.
Phenotypic Screening: The Resurgent Engine for First-in-Class Drug Discovery
This article explores the powerful resurgence of phenotypic screening as a primary driver for discovering first-in-class therapeutics.
Strategic Chemogenomics Library Design for Advanced Phenotypic Screening in Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on designing effective chemogenomics libraries for phenotypic assays.
Phenotypic vs. Target-Based Drug Discovery: A Modern Guide to Strategies, Successes, and AI Integration
This article provides a comprehensive analysis of the two dominant paradigms in pharmaceutical research: phenotypic drug discovery (PDD) and target-based drug discovery (TDD).
Cell Painting and Morphological Profiling: A Comprehensive Guide for Phenotypic Screening in Drug Discovery
This article provides a comprehensive overview of morphological profiling using the Cell Painting assay, an image-based high-content screening method that quantifies hundreds of cellular features to capture phenotypic changes.
Chemogenomics Libraries for Target Identification: A Comprehensive Guide for Modern Drug Discovery
This article provides a comprehensive examination of chemogenomics libraries as powerful tools for target identification in phenotypic drug discovery.
System Pharmacology Networks in Phenotypic Screening: A New Paradigm for First-in-Class Drug Discovery
This article explores the powerful integration of system pharmacology networks with phenotypic screening, a strategy redefining modern drug discovery.