Research Articles
Covalent Poisons of Topoisomerase II: The Molecular Scissors That Turn Fatal
Explore how covalent topoisomerase II poisons weaponize essential DNA enzymes to create powerful cancer therapies and the scientific breakthroughs driving this field.
The Guardian's Betrayal: When DNA Turns Against the p53 Cancer Fighter
Discover how damaged DNA can actively sabotage the p53 cancer fighter, triggering a vicious cycle that may accelerate cancer and aging through DNA-mediated oxidation.
Beyond the Nucleus: The Hidden World of Membrane Steroid Receptors in Cancer
Discover how membrane steroid receptors are revolutionizing our understanding of hormone-sensitive cancers and opening new avenues for targeted treatments.
Cracking the Cancer Code: How a Dog’s Genome Is Helping Save Children’s Lives
Discover how cross-species genomic research between humans and dogs is identifying novel driver genes in embryonal rhabdomyosarcoma, a devastating childhood cancer.
The p53 Resurrection: How Restoring a "Guardian Gene" Overcomes Drug Resistance in Cancer
Discover how restoring wild-type p53 activity in p53-null HL-60 cells can re-sensitize them to chemotherapy and overcome drug resistance in cancer.
The eccDNA Revolution: Unlocking Cancer's Circular Secrets with a Lab Breakthrough
Discover how breakthroughs in eccDNA synthesis are revolutionizing cancer research and treatment possibilities.
Aneuploidy Alert: How Cellular Chaos Triggers Cancer's Self-Destruct Button
Exploring how Aurora B kinase inhibition triggers cancer cell self-destruction through aneuploidy-induced p21 activation
Nature's Pharmacy Meets AI: Predicting Cancer's Weakness to Natural Compounds
How machine learning algorithms predict cancer cell sensitivity to natural products by decoding genomic and chemical blueprints