Research Articles
Chemogenomic Libraries in Phenotypic Screening: A Strategic Guide for Performance and Application in Drug Discovery
This article provides a comprehensive analysis of chemogenomic libraries and their performance in phenotypic screening, a powerful approach for first-in-class drug discovery.
Validating Chemogenomic Libraries for Phenotypic Screening: Strategies for Unlocking Novel Drug Targets
This article provides a comprehensive guide for researchers and drug development professionals on the validation of chemogenomic libraries for phenotypic screening.
Nuclear Morphology Analysis: A Deep Learning Biomarker for Cell Health Assessment in Aging and Disease
This article explores the transformative role of nuclear morphology as a biomarker for cellular health, with a specific focus on applications in aging research and drug development.
Overcoming Solubility Challenges in Phenotypic Screening: Strategies for Reliable Bioactivity Data
This article provides a comprehensive guide for researchers and drug development professionals on managing poorly water-soluble compounds in phenotypic assays.
Kinetic Profiling in Cytotoxicity Phenotypic Screening: Advancing Predictive Drug Discovery
This article explores the integration of kinetic profiling with phenotypic cytotoxicity screening, a transformative approach for modern drug discovery.
Target Deconvolution in Phenotypic Screening: Overcoming Challenges to Unlock First-in-Class Therapies
Phenotypic drug discovery (PDD) has re-emerged as a powerful strategy for identifying first-in-class therapeutics, often acting through novel mechanisms.
Overcoming Morphological Profiling Data Analysis Challenges: From Classical Features to Self-Supervised Learning
Morphological profiling through high-content imaging, particularly the Cell Painting assay, has emerged as a powerful technology for drug discovery and functional genomics.
Strategic Cell Health Assessment: A Guide to Effective Compound Toxicity Filtering in Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on leveraging cell health assessment for early and predictive compound toxicity filtering.
Optimizing Dye Concentrations for Live-Cell Phenotypic Screening: A Guide to Enhanced Assay Performance
Live-cell phenotypic screening provides dynamic, real-time insights into cellular responses but requires careful optimization of dye concentrations to balance signal intensity with cell viability.
Combating Compound Interference in Phenotypic High Content Screening: Strategies for AI-Driven, Reproducible Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on addressing the critical challenge of compound interference in phenotypic High Content Screening (HCS).