Research Articles
Target Deconvolution Strategies: Bridging Phenotypic Screening to Mechanistic Insight in Drug Discovery
This article provides a comprehensive overview of target deconvolution, the essential process of identifying the molecular targets of bioactive compounds discovered through phenotypic screening.
Live-Cell Multiped Assays for Chemogenomic Libraries: A Comprehensive Guide from Screening to Validation
This article provides a comprehensive overview of live-cell multiplexed assays tailored for chemogenomic library screening.
Beyond the Pixel: Advanced Morphological Feature Extraction for Next-Generation Phenotypic Profiling in Drug Discovery
This article provides a comprehensive overview of modern morphological feature extraction techniques and their transformative impact on phenotypic profiling, particularly in biomedical research and drug development.
Scaffold Analysis in Chemogenomic Libraries: Strategies for Enhancing Diversity and Drug Discovery Success
This article provides a comprehensive overview of scaffold analysis and its critical role in evaluating and enhancing the diversity of chemogenomic libraries for modern drug discovery.
Cell Painting Assay: A Comprehensive Guide to Phenotypic Chemogenomic Screening in Drug Discovery
This article provides a current and comprehensive overview of the Cell Painting assay, a high-content, image-based morphological profiling technique central to modern phenotypic chemogenomic screening.
Optimizing High-Content Phenotypic Screening Protocols: From Foundational Principles to AI-Enhanced Workflows
This article provides a comprehensive guide for researchers and drug development professionals on optimizing high-content phenotypic screening (HCS) protocols.
High-Content Imaging in Phenotypic Screening: A Chemogenomic Approach to Modern Drug Discovery
This article explores the integration of high-content imaging (HCI) and chemogenomic libraries in phenotypic screening, a powerful strategy revitalizing drug discovery.
Chemogenomics Libraries: Unlocking the Druggable Genome for Targeted Drug Discovery
This article provides a comprehensive overview of chemogenomics libraries, which are rationally assembled collections of small molecules designed to systematically probe the druggable genome.
Phenotypic Screening for Novel Mechanism of Action (MoA) Discovery: Strategies, AI Integration, and Future Directions
This article provides a comprehensive overview of phenotypic screening as a powerful, unbiased strategy for discovering novel therapeutic mechanisms of action.
Phenotypic Screening: The Resurgent Engine for First-in-Class Drug Discovery
This article explores the powerful resurgence of phenotypic screening as a primary driver for discovering first-in-class therapeutics.